Sabtu, 21 Desember 2013

Get Free Ebook , by Barry Werth

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Product details

File Size: 2063 KB

Print Length: 481 pages

Publisher: Simon & Schuster; Revised ed. edition (August 20, 2013)

Publication Date: August 20, 2013

Sold by: Simon and Schuster Digital Sales Inc

Language: English

ASIN: B00AK78PTG

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Amazon Best Sellers Rank:

#175,971 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Chronicling the rise of Vertex, one of the first companies to dabble in rational drug design, the Billion Dollar Molecule follows the brilliant Josh Boger as he attempts to become the next Merck. The scope of scientific context and the way in which the author weaves together various players is both witty and insightful. However I couldn't help feeling that the author's journalistic prowess obscured and glossed over the actual science that Vertex and its counterparts were performing. As somebody who was hoping for a sort of Elegant Universe meets the pharmaceutical industry structured within a compelling narrative, I was disappointed. The narrative (specifically the sequence of causality dating back from the 1900s to the 1980s) is brilliant, but the science, the real red meat of a book like this, is largely absent.

Barry Werth's book provides a view of the high business and personal risks involved in developing drugs. $ 100 million and much more are sought after to research and develop a drug that only has a promise and could easily do nothing or even worse cause harm. That's the business risk and the leaders have to put on a confident front and do whatever or say whatever to make sure the money keeps coming in. On the personal side many extremely bright and confident PhD/MDs battle it out to be the one that makes the discovery or get credit for it. Quite often this battle is in the same company between friends and colleagues who may not in the end remain as such. Much of it reminds you of high school but then again we probably never do leave that stage as much as we like to think.The constant use of molecule and target names and descriptions can make a difficult read but there is much more soap opera than science. One finishes the book wondering how we have come so far in medicine/pharmaceuticals but I guess the same competitive spirit that can so often get in the way of progress also can make it go further and its tough to know when its more trouble than benefit.

I found this book and story to offer me a new perspective on biotech start-ups and drug development. The financing was also very interesting. Unfortunately, at several points in the book, I found the story dragging and belabored. Overall, it was a worthwhile read for anyone who would like more insight into today's world of biotech.

I purchased this book when I was hired at Vertex. I realize the book is a bit dated now but it is extremely interesting to read about the beginnings of the company and talking to colleagues who worked side by side with some of the people mentioned.The drive and ambition paired with world class talent and intelligence of all the scientists and businessmen is almost unbelievable and should make anyone more motivated to do and be more. I highly recommend giving it a read especially if you are in the biotech field.

This is a dense book to read. Heavy on science (with numerous different science disciplines) and the details of funding an early stage company, make the (presumed) exciting success story difficult to see clearly.

I read this book years ago, yet recall most of its details. It tells the tale of Josh Boger who came out of Harvard to start Vertex Pharmaceuticals, taking you in a captivating fashion through every delicate step from inception to maturity of this company in its quest for the big drug score.Having spent almost 18 years in this industry as a scientist and entrepreneur myself I can testify to its accurate portrayl of what it is like to start a typical therapeutic biotech. This book provides unique incite into the world of start-up biotechs and the risks that come with them. It even manages to scuttle through the many interesting dynamics of biotech personalities where primadonna scientific wiz kids meet bottom line suits with calculators and some hybridize into a combination of the two.If you are a potential investor, wish to work in this industry, or already do or even a patient wondering why your treatment/cure is not yet on market and want to understand more about the economics of biotechnology and drug discovery and development from the ground up, this is a must read. It will edify you and entertain you at the same time and you will end up rooting for Josh along the way.

An insightful book into the rise and fall of a new pharceutical start-up. What fascinates me is the narrative as well as the emotions, motives and Drivers of each individual behind the sciences.

This book is bloody brilliant. Follows Joshua Boger and crew as they take Vertex from an idea to a working pharmaceutical company. Along the way it outlines the history of several others outside the company and how their work influenced the projects chosen within the company. The writing is clear and one is left with a palpable sense of excitement for both the science and the biotech industry in general.

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Download King Leopold's Ghost: A Story of Greed, Terror, and Heroism in Colonial Africa, by Adam Hochschild

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King Leopold's Ghost: A Story of Greed, Terror, and Heroism in Colonial Africa, by Adam Hochschild

King Leopold's Ghost: A Story of Greed, Terror, and Heroism in Colonial Africa, by Adam Hochschild


King Leopold's Ghost: A Story of Greed, Terror, and Heroism in Colonial Africa, by Adam Hochschild


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King Leopold's Ghost: A Story of Greed, Terror, and Heroism in Colonial Africa, by Adam Hochschild

Amazon.com Review

King Leopold of Belgium, writes historian Adam Hochschild in this grim history, did not much care for his native land or his subjects, all of which he dismissed as "small country, small people." Even so, he searched the globe to find a colony for Belgium, frantic that the scramble of other European powers for overseas dominions in Africa and Asia would leave nothing for himself or his people. When he eventually found a suitable location in what would become the Belgian Congo, later known as Zaire and now simply as Congo, Leopold set about establishing a rule of terror that would culminate in the deaths of 4 to 8 million indigenous people, "a death toll," Hochschild writes, "of Holocaust dimensions." Those who survived went to work mining ore or harvesting rubber, yielding a fortune for the Belgian king, who salted away billions of dollars in hidden bank accounts throughout the world. Hochschild's fine book of historical inquiry, which draws heavily on eyewitness accounts of the colonialists' savagery, brings this little-studied episode in European and African history into new light. --Gregory McNamee

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From Publishers Weekly

Hochschild's superb, engrossing chronicle focuses on one of the great, horrifying and nearly forgotten crimes of the century: greedy Belgian King Leopold II's rape of the Congo, the vast colony he seized as his private fiefdom in 1885. Until 1909, he used his mercenary army to force slaves into mines and rubber plantations, burn villages, mete out sadistic punishments, including dismemberment, and committ mass murder. The hero of Hochschild's highly personal, even gossipy narrative is Liverpool shipping agent Edmund Morel, who, having stumbled on evidence of Leopold's atrocities, became an investigative journalist and launched an international Congo reform movement with support from Mark Twain, Booker T. Washington and Arthur Conan Doyle. Other pivotal figures include Joseph Conrad, whose disgust with Leopold's "civilizing mission" led to Heart of Darkness; and black American journalist George Washington Williams, who wrote the first systematic indictment of Leopold's colonial regime in 1890. Hochschild (The Unquiet Ghost) documents the machinations of Leopold, who won over President Chester A. Arthur and bribed a U.S. senator to derail Congo protest resolutions. He also draws provocative parallels between Leopold's predatory one-man rule and the strongarm tactics of Mobuto Sese Seko, who ruled the successor state of Zaire. But most of all it is a story of the bestiality of one challenged by the heroism of many in an increasingly democratic world. 30 illustrations. Agent: Georges Borchardt. First serial rights to American Scholar. Author tour. Copyright 1998 Reed Business Information, Inc.

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Product details

Hardcover: 366 pages

Publisher: Houghton Mifflin; 1St Edition edition (September 1, 1998)

Language: English

ISBN-10: 2702823319

ISBN-13: 978-2702823316

ASIN: 0395759242

Product Dimensions:

6.5 x 1.2 x 9.5 inches

Shipping Weight: 1.6 pounds (View shipping rates and policies)

Average Customer Review:

4.6 out of 5 stars

705 customer reviews

Amazon Best Sellers Rank:

#400,245 in Books (See Top 100 in Books)

Well this is an impressive book, I'm sure there are numerous really good reviews so I'll add something that might be a new observation, reading about British (and Irish) Counsel Roger Casement it reminded me that I read about him before and I looked up and found the story in Charles Mann book 1493 uncovering the new world Columbus created. It's always a thrill to find like a intellectual Easter egg especially if it's unexpected. One of the strengths of this book was how it introduced us to so many persons that are little noticed by history but had large impacts on the world, they came together to fight against one of the great crimes of the day King Leopold's rape and murderous rule of the Congo, they were rather successful over time although the guilty as is almost always the case in these types of crimes went largely unpunished accept for how they are view in history. Reverend William Sheppard sounds like an amazing man, so too with E. D. Morel, if it wasn't for this book I would know nothing of their stories. The difficulty of conducting this research when the main principals did everything they could to destroy the cover over there deeds, the remoteness of the area and the time period, makes it a miracle that this book could be written at all. Very glad I read it I've created a new shelf called Excellent History books just for books like this although their can't be many such books that reach this depth and understanding, it will always stand out in that shelf as a must read history book.

So I don't usually do leave reviews of books but I had to this time. I bought this books about 8 Pontus ago but I read the last few weeks only and I think it was the perfect timing with what is going on in my life right now as I'm making big choices concerning my future right now. If I didn't read this book right I probably would have missed on what might just be my life goal and something I plan on focusing for a good part of my life once I get more ready for it. I know this is not much of a book review as of now but I just wanted to show how much the story of my people have affected me and how I really want to do something about all the suffering that have been going and keeps on happening now. I myself grew up in Kinshasa, my dad was an army colonel who fought against Mobutu in the 90's and had to flee the country for a few years because of that. This year (2017) I'm about tombe 18 and I surprised that it's only now that I get to know the story of my people and what that so-called King Léopold II have done. Throughout my read I came to decide that one day I want to be a change in my countries history too, a positive change, I want to be the African voice to change the Congo and make it one of the great countries. I know I sound a little too exited now and kind of dreaming but I'm still a kid so I guess it's okay right? One day hopefully once I do start making a change someone finds this "review" and call me out on it.

I bought this book on a whim while on vacation because it was a Kindle Daily Deal, and wound up finishing it in just three days. I have no real background in Africa, Belgium, or colonialism, but Hochschild does a phenomenal job of weaving together a compelling story that brings a forgotten and disgraceful era to life.The story is just incredible. Chronologically, Hochschild does a great job at tying together a complex story over decades and even centuries, beginning with tale of the European discovery of the Congo river and then honing in on Leopold's obsession with colonial expansion and the Congo specifically. He describes the casual brutality of Leopold's regime extremely effectively before skillfully introducing the figures in the movement that rose up to make the world aware of what was happening in Africa. Along the way, the author does a great job of putting the events into historical context and addressing likely counterarguments made be pro-Leopold sources (e.g. why there was outrage about the Congo specifically despite equally brutal colonial regimes elsewhere in Africa, the pre-existence of continental African slavery, etc). Hochschild does a great job of developing characters and presents a mountain of irrefutable evidence to back up his main arguments, all of which is done in an extremely engaging manner. The author's epilogue, written 10 years after the initial publication, is also even handed and insightful.If I have any complaint with the book, it's that the author sometimes makes leaps of judgement in the narrative that aren't necessary, especially when it comes to speculating whether certain characters in the story previously l crossed paths or allowed specific people/events to privately influence their decisions. The story is compelling enough without these speculations. He also (rightfully) demonizes Leopold and other figures in the regime, but spends less time characterizing anti-colonial figures whose backgrounds and personal lives are shady at best. While certain players are demonstrably more despicable than others, I felt that Hochschild could have been a little more even handed in describing the faults of his protagonists at times, if for nothing else than to appear more impartial as a narrator and derail his critics.Overall, the book is outstanding and I would recommend it to anybody looking for a fast paced story, context about the European scramble for Africa, or insight as to how Africa developed through the 20th century.

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Jumat, 06 Desember 2013

Get Free Ebook Five Fundamentals: Steve Elkington Reveals the Secrets of the Best Swing in Golf, by Steve Elkington

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Five Fundamentals: Steve Elkington Reveals the Secrets of the Best Swing in Golf, by Steve Elkington


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Five Fundamentals: Steve Elkington Reveals the Secrets of the Best Swing in Golf, by Steve Elkington

Amazon.com Review

Ask any foursome of professional golfers who possesses the most sound swing on tour, and the response will be a gimme: Australian Steve Elkington. In Fundamentals, the PGA champ tees up his secrets, breaking down the essentials into pretty much the same pentathlon--grip, set-up, backswing, downswing, and tempo--as the great Ben Hogan did in his '50s classic, Five Lessons. Elkington's style is anecdotal, personal, conversational, and friendly; he talks you through his methods and thinking, with an emphasis on getting things right from the start rather than fixing faults acquired along the way. Throughout, he offers particular tips for advanced players, and he ends with useful advice on equipment, a section geared specifically to shoring up the short game, and an excellent series of exercises geared to keep golfing muscles loose and limber. Where Five Fundamentals really scores is in its ability to show as well as tell. It is peppered with helpful still photographs. Better yet, the top and bottom corners of the pages use the old flicker technique; flip them quickly and you'll be able to see Elk's sweet swing in action whacking a driver, a six-iron, and a wedge from the sand. In his hands, it looks so easy; the challenge is making yours look the same. --Jeff Silverman

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From the Inside Flap

tched PGA champion Steve Elkington play golf, you know what the perfect swing looks like in action: an elegant, apparently effortless stroke with stunningly accurate force. Now in this instructive book, Elkington shares the techniques and strategies behind that trademark swing, which his colleagues have named Best on Tour five years running. The secret is mastering the Five Fundamentals--the grip, the setup, the backswing, the downswing, and tempo.

"My aim is to provide a benchmark, a basis on which any player can build his own, authentic swing," Elkington writes. "I won't discuss faults or fixes. Golf is a series of linked fundamentals; let's eliminate your faults from the moment you pick up the club."

Applying the "flicker" or "flip book" technique in swing sequences with the driver, six-iron, and sand wedge, Five Fundamentals shows the rhythm and balance of Elkington's motion better than any still photograph could convey. Combining t

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Product details

Hardcover: 174 pages

Publisher: Ballantine Books; 1st edition (October 20, 1998)

Language: English

ISBN-10: 0345421523

ISBN-13: 978-0345421524

Product Dimensions:

7.8 x 0.8 x 9.8 inches

Shipping Weight: 1.6 pounds (View shipping rates and policies)

Average Customer Review:

3.3 out of 5 stars

9 customer reviews

Amazon Best Sellers Rank:

#415,708 in Books (See Top 100 in Books)

This is just a so,so book on golf. I was disappointed in it because I have watched Elkington on "in the Dirt" videos and he is very knowledgeable and very insightful about he golf swing. This just didn't compare.

Boght the book bunMr. Elkington cause I caddied once for him in the dutch open as a kid... Way before he became a world clas golfer! Hope it is an interesting read.

just as described quickly shipped

Like most golf books, you learn next to nothing. Elkington has one of the great swings of all time but it's unlikely you'll mimic it after reading his book. Poor quality photos.

Possessing one of the simpliest and classically crafted golf swings of any professional, Steve Elkington makes the vision come to life with excellent practical instruction accompanied by wonderful photographs. The format is basically the same as the Hogan classic. Starting with grip, and proceeding to downswing and follow-through, Elkington's interpretation is fresh and better explained than Hogan's. The drawings in the Hogan book are still classic and in Elkington's book are replaced by great photographs. Read the section on the grip and what to do with the thumbs, I'm sure you'll find that tip alone is something you haven't heard and well worth the price. This book belongs in every comprehensive golf library.

Steve Elkington provides all that is needed as a foundation for an effective and efficient golf swing. I have read many instuctional books which(unfortunately) present an overabundance of techniques or concepts ... so much that they lose their focus on what is being presented as the key concepts or fundamentals for an effective swing. Elkington has narrowed these key points to 5. And, from early personal experience, these 5 keys or fundamentals are "right on". Of course, they can't be learned or ingrained overnight. Patience will be required, but Steve Elkington is "proof-positive" that they are effective.

I found this book enlightening, particularly with regard to the section on transition. I have squandered years trying to figure out how to get from backswing to forward swing and this book finally allowed the "light to go off." His explanation on lowering and then raising the shoulder to initiate swings for the short game and putting are ridiculously simple. Having said that, I must say that it is a joke that the binding of this book literally disintegrates with use. I have bought 2 books thinking that the first one was just a fluke but, unfortunately both fell apart in my hands. Shame on Ballantine Books for allowing such shoddy workmanship.

Steve Elkington is not only a marvelous golfer but he is an accomplished horticulturist and a great family man. His approach to the golf game is one of extreme intelligence. He can improve a golfer's game tremendously if they follow his advice on the fundamentals outlined in this book. I only wish I had read this book 40 years ago! Now he needs to write a book on "course management".

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Five Fundamentals: Steve Elkington Reveals the Secrets of the Best Swing in Golf, by Steve Elkington PDF

Five Fundamentals: Steve Elkington Reveals the Secrets of the Best Swing in Golf, by Steve Elkington PDF
Five Fundamentals: Steve Elkington Reveals the Secrets of the Best Swing in Golf, by Steve Elkington PDF
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Rabu, 04 Desember 2013

PDF Download Your College Experience: Study Skills Edition: Strategies for Success

PDF Download Your College Experience: Study Skills Edition: Strategies for Success

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Your College Experience: Study Skills Edition: Strategies for Success

Your College Experience: Study Skills Edition: Strategies for Success


Your College Experience: Study Skills Edition: Strategies for Success


PDF Download Your College Experience: Study Skills Edition: Strategies for Success

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Your College Experience: Study Skills Edition: Strategies for Success

About the Author

John N. Gardner brings unparalleled experience to students as an author. The recipient of his institution's highest award for teaching excellence, John has over forty years of experience directing and teaching in the most widely emulated first-year seminar in the country, the University 101 course at the University of South Carolina (USC), Columbia. John is universally recognized as one of the country's leading educators for his role in initiating and orchestrating an international reform movement to improve the beginning college experience, a concept he coined as "the first-year experience." He is the founding executive director of the National Resource Center for The First-Year Experience and Students in Transition at USC, as well as the Policy Center on the First Year of College and the John N. Gardner Institute for Excellence in Undergraduate Education (www.jngi.org), both based in Brevard, N.C. Betsy O. Barefoot is a writer, researcher, and teacher whose special area of scholarship is the first-year seminar. During her tenure at USC from 1988 to 1999, she served as codirector for research and publications at the National Resource Center for The First-Year Experience and Students in Transition. She also taught University 101 and graduate courses on the first-year experience and the principles of college teaching. She conducts first-year seminar faculty training workshops around the world and is frequently called on to evaluate first-year seminar outcomes. Betsy is codirector and senior scholar in the Policy Center on the First Year of College and Vice President of the John N. Gardner Institute for Excellence in Undergraduate Education both in Brevard, N.C. In her Policy Center role she led a major national research project to identify institutions of excellence in the first college year. She currently works with both two- and four-year campuses in evaluating all components of the first year.

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Product details

Paperback: 256 pages

Publisher: Bedford/St. Martin's; Tenth edition (December 14, 2012)

Language: English

ISBN-10: 1457625741

ISBN-13: 978-1457625749

Product Dimensions:

8.5 x 0.5 x 10.9 inches

Shipping Weight: 1.1 pounds (View shipping rates and policies)

Average Customer Review:

5.0 out of 5 stars

2 customer reviews

Amazon Best Sellers Rank:

#876,061 in Books (See Top 100 in Books)

I would've paid four times as much at the college bookstore for the exact same book.THANK YOU SO VERY MUCH .

As expected!!

Your College Experience: Study Skills Edition: Strategies for Success PDF
Your College Experience: Study Skills Edition: Strategies for Success EPub
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Your College Experience: Study Skills Edition: Strategies for Success iBooks
Your College Experience: Study Skills Edition: Strategies for Success rtf
Your College Experience: Study Skills Edition: Strategies for Success Mobipocket
Your College Experience: Study Skills Edition: Strategies for Success Kindle

Your College Experience: Study Skills Edition: Strategies for Success PDF

Your College Experience: Study Skills Edition: Strategies for Success PDF

Your College Experience: Study Skills Edition: Strategies for Success PDF
Your College Experience: Study Skills Edition: Strategies for Success PDF
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