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, by Barry Werth
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Product details
File Size: 2063 KB
Print Length: 481 pages
Publisher: Simon & Schuster; Revised ed. edition (August 20, 2013)
Publication Date: August 20, 2013
Sold by: Simon and Schuster Digital Sales Inc
Language: English
ASIN: B00AK78PTG
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Amazon Best Sellers Rank:
#175,971 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
Chronicling the rise of Vertex, one of the first companies to dabble in rational drug design, the Billion Dollar Molecule follows the brilliant Josh Boger as he attempts to become the next Merck. The scope of scientific context and the way in which the author weaves together various players is both witty and insightful. However I couldn't help feeling that the author's journalistic prowess obscured and glossed over the actual science that Vertex and its counterparts were performing. As somebody who was hoping for a sort of Elegant Universe meets the pharmaceutical industry structured within a compelling narrative, I was disappointed. The narrative (specifically the sequence of causality dating back from the 1900s to the 1980s) is brilliant, but the science, the real red meat of a book like this, is largely absent.
Barry Werth's book provides a view of the high business and personal risks involved in developing drugs. $ 100 million and much more are sought after to research and develop a drug that only has a promise and could easily do nothing or even worse cause harm. That's the business risk and the leaders have to put on a confident front and do whatever or say whatever to make sure the money keeps coming in. On the personal side many extremely bright and confident PhD/MDs battle it out to be the one that makes the discovery or get credit for it. Quite often this battle is in the same company between friends and colleagues who may not in the end remain as such. Much of it reminds you of high school but then again we probably never do leave that stage as much as we like to think.The constant use of molecule and target names and descriptions can make a difficult read but there is much more soap opera than science. One finishes the book wondering how we have come so far in medicine/pharmaceuticals but I guess the same competitive spirit that can so often get in the way of progress also can make it go further and its tough to know when its more trouble than benefit.
I found this book and story to offer me a new perspective on biotech start-ups and drug development. The financing was also very interesting. Unfortunately, at several points in the book, I found the story dragging and belabored. Overall, it was a worthwhile read for anyone who would like more insight into today's world of biotech.
I purchased this book when I was hired at Vertex. I realize the book is a bit dated now but it is extremely interesting to read about the beginnings of the company and talking to colleagues who worked side by side with some of the people mentioned.The drive and ambition paired with world class talent and intelligence of all the scientists and businessmen is almost unbelievable and should make anyone more motivated to do and be more. I highly recommend giving it a read especially if you are in the biotech field.
This is a dense book to read. Heavy on science (with numerous different science disciplines) and the details of funding an early stage company, make the (presumed) exciting success story difficult to see clearly.
I read this book years ago, yet recall most of its details. It tells the tale of Josh Boger who came out of Harvard to start Vertex Pharmaceuticals, taking you in a captivating fashion through every delicate step from inception to maturity of this company in its quest for the big drug score.Having spent almost 18 years in this industry as a scientist and entrepreneur myself I can testify to its accurate portrayl of what it is like to start a typical therapeutic biotech. This book provides unique incite into the world of start-up biotechs and the risks that come with them. It even manages to scuttle through the many interesting dynamics of biotech personalities where primadonna scientific wiz kids meet bottom line suits with calculators and some hybridize into a combination of the two.If you are a potential investor, wish to work in this industry, or already do or even a patient wondering why your treatment/cure is not yet on market and want to understand more about the economics of biotechnology and drug discovery and development from the ground up, this is a must read. It will edify you and entertain you at the same time and you will end up rooting for Josh along the way.
An insightful book into the rise and fall of a new pharceutical start-up. What fascinates me is the narrative as well as the emotions, motives and Drivers of each individual behind the sciences.
This book is bloody brilliant. Follows Joshua Boger and crew as they take Vertex from an idea to a working pharmaceutical company. Along the way it outlines the history of several others outside the company and how their work influenced the projects chosen within the company. The writing is clear and one is left with a palpable sense of excitement for both the science and the biotech industry in general.
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